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Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling
The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen‐activated protein kinase (MAPK) plays a pivotal role in regulating its transcriptional activity and stabil...
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| Udgivet i: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7202204/ https://ncbi.nlm.nih.gov/pubmed/32103600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948693 |
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