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Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling

The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen‐activated protein kinase (MAPK) plays a pivotal role in regulating its transcriptional activity and stabil...

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Podrobná bibliografie
Vydáno v:EMBO Rep
Hlavní autoři: Park, Dong‐Seok, Yoon, Gang‐Ho, Kim, Eun‐Young, Lee, Taehyeong, Kim, Kyuhee, Lee, Peter CW, Chang, Eun‐Ju, Choi, Sun‐Cheol
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202204/
https://ncbi.nlm.nih.gov/pubmed/32103600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948693
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