Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-r...

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Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Bogie, Jeroen F.J., Grajchen, Elien, Wouters, Elien, Corrales, Aida Garcia, Dierckx, Tess, Vanherle, Sam, Mailleux, Jo, Gervois, Pascal, Wolfs, Esther, Dehairs, Jonas, Van Broeckhoven, Jana, Bowman, Andrew P., Lambrichts, Ivo, Gustafsson, Jan-Åke, Remaley, Alan T., Mulder, Monique, Swinnen, Johannes V., Haidar, Mansour, Ellis, Shane R., Ntambi, James M., Zelcer, Noam, Hendriks, Jerome J.A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201924/
https://ncbi.nlm.nih.gov/pubmed/32097464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191660
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