Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-r...

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Publicat a:J Exp Med
Autors principals: Bogie, Jeroen F.J., Grajchen, Elien, Wouters, Elien, Corrales, Aida Garcia, Dierckx, Tess, Vanherle, Sam, Mailleux, Jo, Gervois, Pascal, Wolfs, Esther, Dehairs, Jonas, Van Broeckhoven, Jana, Bowman, Andrew P., Lambrichts, Ivo, Gustafsson, Jan-Åke, Remaley, Alan T., Mulder, Monique, Swinnen, Johannes V., Haidar, Mansour, Ellis, Shane R., Ntambi, James M., Zelcer, Noam, Hendriks, Jerome J.A.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201924/
https://ncbi.nlm.nih.gov/pubmed/32097464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191660
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