A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selecti...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Edwards, Sarah C., Sutton, Caroline E., Ladell, Kristin, Grant, Emma J., McLaren, James E., Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L., Lalor, Stephen J., Ribot, Julie C., Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A., Thomas, Paul G., McLoughlin, Rachel M., Mills, Kingston H.G.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201916/
https://ncbi.nlm.nih.gov/pubmed/32106283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190834
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