Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson’s disease model

BACKGROUND: The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson’s disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that microglia-mediated neuroinflammation contributes to n...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Hou, Liyan, Qu, Xingyue, Qiu, Xiaofei, Huang, Ruixue, Zhao, Xiulan, Wang, Qingshan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201626/
https://ncbi.nlm.nih.gov/pubmed/32375810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01823-3
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