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Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice
BACKGROUND: Mutations in TSC1 or TSC2 genes cause tuberous sclerosis complex (TSC), a disorder associated with epilepsy, autism, and intellectual disability. TSC1 and TSC2 are repressors of the mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of protein synthesis. Dysregulation of...
保存先:
出版年: | Mol Autism |
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主要な著者: | , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
BioMed Central
2020
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7201610/ https://ncbi.nlm.nih.gov/pubmed/32375878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00340-7 |
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