Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice

BACKGROUND: Mutations in TSC1 or TSC2 genes cause tuberous sclerosis complex (TSC), a disorder associated with epilepsy, autism, and intellectual disability. TSC1 and TSC2 are repressors of the mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of protein synthesis. Dysregulation of...

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Publicat a:Mol Autism
Autors principals: Haji, Nabila, Riebe, Ilse, Aguilar-Valles, Argel, Artinian, Julien, Laplante, Isabel, Lacaille, Jean-Claude
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201610/
https://ncbi.nlm.nih.gov/pubmed/32375878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00340-7
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