Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

BACKGROUND: Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool to dissect cell-specific effects of drug treatment in complex tissues. This application requires high levels of precision, robustness, and quantitative accuracy—beyond those achievable with existing methods for mainly qualita...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Marquina-Sanchez, Brenda, Fortelny, Nikolaus, Farlik, Matthias, Vieira, Andhira, Collombat, Patrick, Bock, Christoph, Kubicek, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201533/
https://ncbi.nlm.nih.gov/pubmed/32375897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02006-2
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