Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

OBJECTIVE: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel and colon. Here, we asse...

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Publicado en:Mol Metab
Main Authors: Panaro, Brandon L., Yusta, Bernardo, Matthews, Dianne, Koehler, Jacqueline A., Song, Youngmi, Sandoval, Darleen A., Drucker, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200938/
https://ncbi.nlm.nih.gov/pubmed/32278655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100990
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