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Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells

Remodeling of distal pulmonary arterioles (PAs) associated with marked accumulation of pulmonary artery smooth muscle cells (PASMCs) represents one of the major pathologic features of pulmonary hypertension (PH). We have reported that the transcription factor Twist1 mediates hypoxia-induced PH. Howe...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Mammoto, Akiko, Hendee, Kathryn, Muyleart, Megan, Mammoto, Tadanori
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200682/
https://ncbi.nlm.nih.gov/pubmed/32371931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64298-5
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