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Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells

Remodeling of distal pulmonary arterioles (PAs) associated with marked accumulation of pulmonary artery smooth muscle cells (PASMCs) represents one of the major pathologic features of pulmonary hypertension (PH). We have reported that the transcription factor Twist1 mediates hypoxia-induced PH. Howe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mammoto, Akiko, Hendee, Kathryn, Muyleart, Megan, Mammoto, Tadanori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200682/
https://ncbi.nlm.nih.gov/pubmed/32371931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64298-5
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