Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21

Radiotherapy with or without concurrent chemotherapy is the standard treatment for nasopharyngeal carcinoma (NPC) patients, whose efficacy is limited partly by intrinsic and acquired radioresistance. DNA methyltransferase 3B (DNMT3B) has been reported to participate in tumorigenesis via DNA methylat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Oncolytics
Prif Awduron: Wu, Cheng, Guo, Ergang, Ming, Jun, Sun, Wei, Nie, Xin, Sun, Lu, Peng, Shan, Luo, Min, Liu, Dongbo, Zhang, Linli, Mei, Qi, Long, Guoxian, Hu, Guangyuan, Hu, Guoqing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Gene & Cell Therapy 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200625/
https://ncbi.nlm.nih.gov/pubmed/32382655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.04.007
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