Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21

Radiotherapy with or without concurrent chemotherapy is the standard treatment for nasopharyngeal carcinoma (NPC) patients, whose efficacy is limited partly by intrinsic and acquired radioresistance. DNA methyltransferase 3B (DNMT3B) has been reported to participate in tumorigenesis via DNA methylat...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Wu, Cheng, Guo, Ergang, Ming, Jun, Sun, Wei, Nie, Xin, Sun, Lu, Peng, Shan, Luo, Min, Liu, Dongbo, Zhang, Linli, Mei, Qi, Long, Guoxian, Hu, Guangyuan, Hu, Guoqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200625/
https://ncbi.nlm.nih.gov/pubmed/32382655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.04.007
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