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A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Milanese, Chiara, Mastroberardino, Pier G.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199736/
https://ncbi.nlm.nih.gov/pubmed/32391425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1733383
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