Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

Coronaviruses make use of a large envelope protein called spike (S) to engage host cell receptors and catalyze membrane fusion. Because of the vital role that these S proteins play, they represent a vulnerable target for the development of therapeutics. Here, we describe the isolation of single-doma...

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Pubblicato in:Cell
Autori principali: Wrapp, Daniel, De Vlieger, Dorien, Corbett, Kizzmekia S., Torres, Gretel M., Wang, Nianshuang, Van Breedam, Wander, Roose, Kenny, van Schie, Loes, Hoffmann, Markus, Pöhlmann, Stefan, Graham, Barney S., Callewaert, Nico, Schepens, Bert, Saelens, Xavier, McLellan, Jason S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Inc. 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199733/
https://ncbi.nlm.nih.gov/pubmed/32375025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.04.031
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