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Mannich-type Reactions of Cyclic Nitrones: Effective Methods for the Enantioselective Synthesis of Piperidine-containing Alkaloids

Although there are dozens of biologically active 2-substituted and 2,6-disubstituted piperidines, only a limited number of approaches exist for their synthesis. Herein is described two Mannich-type additions to nitrones, one using β-ketoacids under catalyst-free conditions and another using methyl k...

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Publicado en:Angew Chem Int Ed Engl
Main Authors: Lisnyak, Vladislav G., Lynch-Colameta, Tessa, Snyder, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199385/
https://ncbi.nlm.nih.gov/pubmed/30276949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201809799
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