An Engineered Three-Dimensional Stem Cell Niche in the Inner Ear by Applying a Nanofibrillar Cellulose Hydrogel with a Sustained-Release Neurotrophic Factor Delivery System

Although the application of human embryonic stem cells (hESCs) in stem cell–replacement therapy remains promising, its potential is hindered by a low cell survival rate in post-transplantation within the inner ear. Here, we aim to enhance the in vitro and in vivo survival rate and neuronal different...

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Bibliographic Details
Published in:Acta Biomater
Main Authors: Chang, Hsiang-Tsun, Heuer, Rachel A., Oleksijew, Andrew M., Coots, Kyle S., Roque, Christian B., Nella, Kevin T., McGuire, Tammy L., Matsuoka, Akihiro J.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198367/
https://ncbi.nlm.nih.gov/pubmed/32156626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2020.03.007
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