Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

Normothermic perfusion provides a means to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new drug combinations to trigger defatting in three human culture models, primary hepatocytes with induced steatosis, primary hepatocytes isolat...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Aoudjehane, Lynda, Gautheron, Jérémie, Le Goff, Wilfried, Goumard, Claire, Gilaizeau, Julia, Nget, Chan Sonavine, Savier, Eric, Atif, Muhammad, Lesnik, Philippe, Morichon, Romain, Chrétien, Yves, Calmus, Yvon, Scatton, Olivier, Housset, Chantal, Conti, Filomena
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197711/
https://ncbi.nlm.nih.gov/pubmed/32094147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.042663
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