Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons

Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor essential in dorsal neural tube progenitors for specification of these inhibitory neurons. Thus, mechanisms regulating Ptf1a expression are ke...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Mona, Bishakha, Villarreal, Juan, Savage, Trisha K., Kollipara, Rahul K., Boisvert, Brooke E., Johnson, Jane E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197352/
https://ncbi.nlm.nih.gov/pubmed/32241803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.332577.119
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