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Amelotin is expressed in retinal pigment epithelium and localizes to hydroxyapatite deposits in dry age-related macular degeneration

Deposition of hydroxyapatite (HAP) basal to the retinal pigment epithelium (RPE) is linked to the progression of age-related macular degeneration (AMD). Serum-deprivation of RPE cells in culture mimics some features of AMD. We now show that serum-deprivation also leads to the induction of amelotin (...

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Detalhes bibliográficos
Publicado no:Transl Res
Main Authors: RAJAPAKSE, DINUSHA, PETERSON, KATHERINE, MISHRA, SANGHAMITRA, FAN, JIANGUO, LERNER, JOSHUA, CAMPOS, MARIA, WISTOW, GRAEME
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197213/
https://ncbi.nlm.nih.gov/pubmed/32160961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2020.02.007
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