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Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of Age-related Macular Degeneration
Retinal pigment epithelium (RPE) has been implicated as key source of cholesterol-rich deposits at Bruch’s membrane (BrM) and in drusen in aging human eye. We have shown that serum-deprivation of confluent RPE cells is associated with upregulation of cholesterol synthesis and accumulation of unester...
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| Pubblicato in: | Exp Cell Res |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5701823/ https://ncbi.nlm.nih.gov/pubmed/29097185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2017.10.036 |
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