Preclinical Studies of the Off-Target Reactivity of AFP(158)-Specific TCR Engineered T Cells

Autologous T cells engineered with T receptor genes (TCR) are being studied to treat cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha fetoprotein epitope (AFP(158)) complex and have shown that human T cells engineered with these TCR genes (TCR-Ts) can eradi...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cai, Lun, Caraballo Galva, Leidy D., Peng, Yibing, Luo, Xiaobing, Zhu, Wei, Yao, Yihong, Ji, Yun, He, Yukai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196607/
https://ncbi.nlm.nih.gov/pubmed/32395117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00607
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