Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature

BACKGROUND: Ichthyoses are a group of rare skin disorders lacking effective treatments. Although genetic mutations are progressively delineated, comprehensive molecular phenotyping of ichthyotic skin could suggest much-needed pathogenesis-based therapy. OBJECTIVE: We sought to profile the molecular...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Malik, Kunal, He, Helen, Huynh, Thy Nhat, Tran, Gary, Mueller, Kelly, Doytcheva, Kristina, Renert-Yuval, Yael, Czarnowicki, Tali, Magidi, Shai, Chou, Margaret, Estrada, Yeriel D., Wen, Huei-Chi, Peng, Xiangyu, Xu, Hui, Zheng, Xiuzhong, Krueger, James G., Paller, Amy S., Guttman-Yassky, Emma
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195861/
https://ncbi.nlm.nih.gov/pubmed/29803800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.03.021
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