IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution

Follicular lymphoma B cells undergo continuous somatic hypermutation (SHM) of their immunoglobulin variable region genes, generating a heterogeneous tumor population. SHM introduces DNA sequences encoding N-glycosylation sites asparagine-X-serine/threonine (N-gly sites) within the V-region that are...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Odabashian, Mariette, Carlotti, Emanuela, Araf, Shamzah, Okosun, Jessica, Spada, Filomena, Gribben, John G., Forconi, Francesco, Stevenson, Freda K., Calaminici, Mariarita, Krysov, Sergey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195541/
https://ncbi.nlm.nih.gov/pubmed/31932843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002279
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