Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-...

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Publié dans:Nat Commun
Auteurs principaux: Coutzac, Clélia, Jouniaux, Jean-Mehdi, Paci, Angelo, Schmidt, Julien, Mallardo, Domenico, Seck, Atmane, Asvatourian, Vahe, Cassard, Lydie, Saulnier, Patrick, Lacroix, Ludovic, Woerther, Paul-Louis, Vozy, Aurore, Naigeon, Marie, Nebot-Bral, Laetitia, Desbois, Mélanie, Simeone, Ester, Mateus, Christine, Boselli, Lisa, Grivel, Jonathan, Soularue, Emilie, Lepage, Patricia, Carbonnel, Franck, Ascierto, Paolo Antonio, Robert, Caroline, Chaput, Nathalie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195489/
https://ncbi.nlm.nih.gov/pubmed/32358520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16079-x
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