MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

Hyperglycemia activates toll-like receptor 4 (TLR4) to induce inflammation in diabetic cardiomyopathy (DCM). However, the mechanisms of TLR4 activation remain unclear. Here we examine the role of myeloid differentiation 2 (MD2), a co-receptor of TLR4, in high glucose (HG)- and diabetes-induced infla...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Yi, Luo, Wu, Han, Jibo, Khan, Zia A., Fang, Qilu, Jin, Yiyi, Chen, Xuemei, Zhang, Yali, Wang, Meihong, Qian, Jianchang, Huang, Weijian, Lum, Hazel, Wu, Gaojun, Liang, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195432/
https://ncbi.nlm.nih.gov/pubmed/32358497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15978-3
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