Chronic Presence of Oligomeric Aβ Differentially Modulates Spine Parameters in the Hippocampus and Cortex of Mice With Low APP Transgene Expression

Alzheimer’s disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligomeric amyloid-β (Aβ) is thought to play a causative role in this disease, which eventually leads to cognitive decline. However, most animal studies have employed mice expressing high levels of the Aβ pr...

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Detalhes bibliográficos
Publicado no:Front Synaptic Neurosci
Main Authors: Hrynchak, Mariya V., Rierola, Marina, Golovyashkina, Nataliya, Penazzi, Lorène, Pump, Wiebke C., David, Bastian, Sündermann, Frederik, Brandt, Roland, Bakota, Lidia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194154/
https://ncbi.nlm.nih.gov/pubmed/32390822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2020.00016
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