Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway

BACKGROUND: Ischemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons. Of note, hippocampus is more susceptive to cerebral I/R in...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Xu, Fan, Lv, Chun, Deng, Yan, Liu, Yuangui, Gong, Qihai, Shi, Jingshan, Gao, Jianmei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194126/
https://ncbi.nlm.nih.gov/pubmed/32390851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00523
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