Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats

Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline of vascular dementia (VD) as it is conducive to induce beta-amyloid (Aβ) aggregation. Icariside II (ICS II), a plant-derived flavonoid compound, has showed neuroprotective effect on animal models of Alzheime...

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Опубликовано в: :Front Pharmacol
Главные авторы: Yin, Caixia, Deng, Yuanyuan, Liu, Yuangui, Gao, Jianmei, Yan, Lingli, Gong, Qihai
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206175/
https://ncbi.nlm.nih.gov/pubmed/30405422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01211
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