Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. T...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Haematologica
Autores principales: Peiris, Malalage N., Meyer, April N., Nelson, Katelyn N., Bisom-Rapp, Ezra W., Donoghue, Daniel J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193502/
https://ncbi.nlm.nih.gov/pubmed/31439673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.220871
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares