Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

A vaccine based on outer membrane vesicles of pertussis (omvPV) is protective in a mouse-challenge model and induces a broad antibody and mixed Th1/Th2/Th17 response against multiple antigens following subcutaneous immunization. However, this route did not result in mucosal immunity and did not prev...

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Publicado no:Sci Rep
Main Authors: Raeven, René H. M., Rockx-Brouwer, Dedeke, Kanojia, Gaurav, van der Maas, Larissa, Bindels, Tim H. E., ten Have, Rimko, van Riet, Elly, Metz, Bernard, Kersten, Gideon F. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192948/
https://ncbi.nlm.nih.gov/pubmed/32355188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63998-2
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