Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine

The demand for improved pertussis vaccines is urgent due to the resurgence of whooping cough. A deeper understanding of the mode of action of pertussis vaccines is required to achieve this improvement. The vaccine-induced effects of a candidate outer membrane vesicle vaccine (omvPV) and a classical...

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Publicat a:Sci Rep
Autors principals: Raeven, René H. M., Brummelman, Jolanda, Pennings, Jeroen L. A., van der Maas, Larissa, Tilstra, Wichard, Helm, Kina, van Riet, Elly, Jiskoot, Wim, van Els, Cécile A. C. M., Han, Wanda G. H., Kersten, Gideon F. A., Metz, Bernard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131296/
https://ncbi.nlm.nih.gov/pubmed/27905535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38240
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