Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation

Accumulating evidence suggests that a reduction in the number of Foxp3(+) regulatory T cells (Tregs) contributes to the pathogenesis of acute graft-versus-host disease (aGVHD), which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT)....

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Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Su, Xiuhua, Wang, Qianqian, Guo, Wei, Pei, Xiaolei, Niu, Qing, Liu, Maolan, Liu, Yuanyuan, Chen, Song, Feng, Sizhou, He, Yi, Yang, Donglin, Zhang, Rongli, Ma, Qiaoling, Zhai, Weihua, Pang, Aiming, Wei, Jialin, Huang, Yong, Luo, Yuechen, Han, Mingzhe, Feng, Xiaoming, Jiang, Erlie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192841/
https://ncbi.nlm.nih.gov/pubmed/31664223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0312-3
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