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A Novel Cell-Free Fluorescent Assay for HDL Function: Low Apolipoprotein A1 Exchange Rate Associated with Increased Incident Cardiovascular Events

BACKGROUND: Cholesterol efflux capacity is a tissue culture assay for HDL function that is not amenable for high-throughput monitoring of risk assessment. METHODS: We devised a cell-free HDL function assay to measure the exchange rate of exogenous apoA1 into serum HDL using NBD/Alexa647 double-label...

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Publicat a:J Appl Lab Med
Autors principals: Lorkowski, Shuhui Wang, Brubaker, Gregory, Li, Lin, Li, Xinmin S, Hazen, Stanley L, Smith, Jonathan D
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192547/
https://ncbi.nlm.nih.gov/pubmed/32445357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jalm/jfaa002
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