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Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology
KCC2 is a vital neuronal K(+)/Cl(−) co-transporter that is implicated in the etiology of numerous neurological diseases. In normal cells, KCC2 undergoes developmental dephosphorylation at Thr(906) and Thr(1007). We engineered mice with heterozygous phospho-mimetic mutations T906E and T1007E (KCC2(E/...
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| Pubblicato in: | Sci Signal |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192243/ https://ncbi.nlm.nih.gov/pubmed/31615899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay0300 |
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