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Uricase-deficient rat is generated with CRISPR/Cas9 technique
Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 te...
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| Publicado no: | PeerJ |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
PeerJ Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192158/ https://ncbi.nlm.nih.gov/pubmed/32368418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.8971 |
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