Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9

Congenital hyperinsulinism (CHI) is a rare genetic disorder characterized by excess insulin secretion, which results in hypoglycemia. Mutation of sulfonylurea receptor 1 (SUR1), encoded by the ABCC8 gene, is the main cause of CHI. Here, we captured the phenotype of excess insulin secretion through p...

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Publicat a:Sci Rep
Autors principals: Guo, Dongsheng, Liu, Haikun, Ruzi, Aynisahan, Gao, Ge, Nasir, Abbas, Liu, Yanli, Yang, Fan, Wu, Feima, Xu, Guosheng, Li, Yin-xiong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466656/
https://ncbi.nlm.nih.gov/pubmed/28600547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03349-w
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