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Consideration of dornase alfa for the treatment of severe COVID-19 acute respiratory distress syndrome

We propose a likely contribution to severe COVID-19 morbidity by extracellular DNA in neutrophil extracellular traps (NETs). Dornase alfa degrades extracellular DNA to reduce mucus rigidity and accumulation, and was associated with respiratory improvement in a first patient. Dornase alfa should be c...

詳細記述

保存先:
書誌詳細
出版年:New Microbes New Infect
主要な著者: Earhart, A.P., Holliday, Z.M., Hofmann, H.V., Schrum, A.G.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192073/
https://ncbi.nlm.nih.gov/pubmed/32355564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nmni.2020.100689
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