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Consideration of dornase alfa for the treatment of severe COVID-19 acute respiratory distress syndrome
We propose a likely contribution to severe COVID-19 morbidity by extracellular DNA in neutrophil extracellular traps (NETs). Dornase alfa degrades extracellular DNA to reduce mucus rigidity and accumulation, and was associated with respiratory improvement in a first patient. Dornase alfa should be c...
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| Publicado no: | New Microbes New Infect |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7192073/ https://ncbi.nlm.nih.gov/pubmed/32355564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nmni.2020.100689 |
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