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Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss

BACKGROUND: In males with classic Fabry disease, the processes leading to the frequent outcome of ESKD are poorly understood. Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) in various cell types. In the glomerular podocytes, accumulation of GL3 pro...

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Bibliografski detalji
Izdano u:J Am Soc Nephrol
Glavni autori: Najafian, Behzad, Tøndel, Camilla, Svarstad, Einar, Gubler, Marie-Claire, Oliveira, João-Paulo, Mauer, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191924/
https://ncbi.nlm.nih.gov/pubmed/32127409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019050497
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