Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

BACKGROUND: Triple-negative breast cancer (TNBC) is aggressive and has a poor prognosis. Kynurenine 3-monooxygenase (KMO), a crucial kynurenine metabolic enzyme, is involved in inflammation, immune response and tumorigenesis. We aimed to study the role of KMO in TNBC. METHODS: KMO alteration and exp...

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Enregistré dans:
Détails bibliographiques
Publié dans:EBioMedicine
Auteurs principaux: Huang, Tzu-Ting, Tseng, Ling-Ming, Chen, Ji-Lin, Chu, Pei-Yi, Lee, Chia-Han, Huang, Chun-Teng, Wang, Wan-Lun, Lau, Ka-Yi, Tseng, Mei-Fang, Chang, Yuan-Ya, Chiang, Tzu-Yi, Ueng, Yune-Fang, Lee, Hsin-Chen, Dai, Ming-Shen, Liu, Chun-Yu
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191260/
https://ncbi.nlm.nih.gov/pubmed/32268268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102717
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