A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Theivanthiran, Balamayoora, Evans, Kathy S., DeVito, Nicholas C., Plebanek, Michael, Sturdivant, Michael, Wachsmuth, Luke P., Salama, April K.S., Kang, Yubin, Hsu, David, Balko, Justin M., Johnson, Douglas B., Starr, Mark, Nixon, Andrew B., Holtzhausen, Alisha, Hanks, Brent A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190922/
https://ncbi.nlm.nih.gov/pubmed/32017708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133055
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