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Cyclic tensile strain facilitates ossification of the cervical posterior longitudinal ligament via increased Indian hedgehog signaling

The pathomechanisms of initiation and progression of ossification of the posterior longitudinal ligament (OPLL) are unclear. Indian hedgehog (Ihh) and related signaling molecules are key factors in normal enchondral ossification. The purpose of this study is to investigate the contribution of mechan...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sugita, Daisuke, Nakajima, Hideaki, Kokubo, Yasuo, Takeura, Naoto, Yayama, Takafumi, Matsumine, Akihiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190672/
https://ncbi.nlm.nih.gov/pubmed/32350355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64304-w
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