Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment

The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases, including prostate cancer, heart failure, and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it a...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Wang, Leiming, Cheng, Chiang-Min, Qin, Jun, Xu, Mafei, Kao, Chung-Yang, Shi, Jingjing, You, Erli, Gong, Wanchun, Rosa, Laura Pedro, Chase, Peter, Scampavia, Louis, Madoux, Franck, Spicer, Timothy, Hodder, Peter, Xu, H. Eric, Tsai, Sophia Y., Tsai, Ming-Jer
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190335/
https://ncbi.nlm.nih.gov/pubmed/32494682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8031
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