Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function

Grb2-associated-binding protein 1 (Gab1) is a docking/scaffolding molecule known to play an important role in cell growth and survival. Here, we report that Gab1 is decreased in cholinergic neurons in Alzheimer’s disease (AD) patients and in a mouse model of AD. In mice, selective ablation of Gab1 i...

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Veröffentlicht in:Cereb Cortex
Hauptverfasser: Lu, Nan-Nan, Tan, Chao, Sun, Ning-He, Shao, Ling-Xiao, Liu, Xiu-Xiu, Gao, Yin-Ping, Tao, Rong-Rong, Jiang, Quan, Wang, Cheng-Kun, Huang, Ji-Yun, Zhao, Kui, Wang, Guang-Fa, Liu, Zhi-Rong, Fukunaga, Kohji, Lu, Ying-Mei, Han, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189983/
https://ncbi.nlm.nih.gov/pubmed/28591834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhx141
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