Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD) and serum from AD patients contains c...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: Elsherbini, Ahmed, Kirov, Alexander S., Dinkins, Michael B., Wang, Guanghu, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M., Bieberich, Erhard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189561/
https://ncbi.nlm.nih.gov/pubmed/32345374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00931-8
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