Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD) and serum from AD patients contains c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Neuropathol Commun
Egile Nagusiak: Elsherbini, Ahmed, Kirov, Alexander S., Dinkins, Michael B., Wang, Guanghu, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M., Bieberich, Erhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189561/
https://ncbi.nlm.nih.gov/pubmed/32345374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00931-8
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