Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD) and serum from AD patients contains c...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Elsherbini, Ahmed, Kirov, Alexander S., Dinkins, Michael B., Wang, Guanghu, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M., Bieberich, Erhard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189561/
https://ncbi.nlm.nih.gov/pubmed/32345374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00931-8
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