Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease

Lafora disease (LD) is a fatal juvenile epilepsy, characterized by the accumulation of aberrant glucan aggregates called Lafora Bodies (LBs). Delivery of protein-based therapeutics to the central nervous system (CNS) for the clearance of LBs remains a unique challenge in the field. Recently, a human...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharm
Asıl Yazarlar: Austin, Grant L., Simmons, Zoe R., Klier, Jack E., Rondon, Alberto, Hodges, Brad L., Shaffer, Robert, Aziz, Nadine M., McKnight, Tracy R., Pauly, James R., Armstrong, Dustin, Vander Kooi, Craig W., Gentry, Matthew S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189208/
https://ncbi.nlm.nih.gov/pubmed/31329461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00396
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