Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

Lafora disease (LD) is a fatal childhood epilepsy caused by recessive mutations in either the EPM2A or EPM2B gene. A hallmark of LD is the intracellular accumulation of insoluble polysaccharide deposits known as Lafora bodies (LBs) in the brain and other tissues. In LD mouse models, genetic reductio...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Brewer, M. Kathryn, Uittenbogaard, Annette, Austin, Grant L., Segvich, Dyann M., DePaoli-Roach, Anna, Roach, Peter J., McCarthy, John J., Simmons, Zoe R., Brandon, Jason A., Zhou, Zhengqiu, Zeller, Jill, Young, Lyndsay E. A., Sun, Ramon C., Pauly, James R., Aziz, Nadine M., Hodges, Bradley L., McKnight, Tracy, Armstrong, Dustin, Gentry, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774808/
https://ncbi.nlm.nih.gov/pubmed/31353261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.07.002
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