Caloric restriction reverses left ventricular hypertrophy through the regulation of cardiac iron homeostasis in impaired leptin signaling mice

Leptin-deficient and leptin-resistant mice manifest obesity, insulin resistance, and left ventricular hypertrophy (LVH); however, LVH’s mechanisms are not fully understood. Cardiac iron dysregulation has been recently implicated in cardiomyopathy. Here we investigated the protective effects of calor...

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Vydáno v:Sci Rep
Hlavní autoři: An, Hyeong Seok, Lee, Jong Youl, Choi, Eun Bee, Jeong, Eun Ae, Shin, Hyun Joo, Kim, Kyung Eun, Park, Kyung-Ah, Jin, Zhen, Lee, Jung Eun, Koh, Jin Sin, Kwak, Woori, Kim, Won-Ho, Roh, Gu Seob
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188880/
https://ncbi.nlm.nih.gov/pubmed/32346034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64201-2
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